Holders Real Madrid were given a palatable pairing against German side Schalke 04, and last year’s beaten finalists Atletico Madrid come up against Bayer Leverkusen.
Arsenal, finalists in 2006, face Monaco, Italian champions Juventus will have to overcome Borussia Dortmund, and German giants Bayern Munich, who beat Borussia in the 2013 final, play Shakhtar Donetsk.
Swiss outfit Basel’s reward for knocking out Liverpool at the group stage was a match-up with two-time winners Porto.
The last 16 first leg games are scheduled for 17/18 and 24/25 February, with the second legs on 10/11 and 17/18 March.
The final for Europe’s elite club competition will take place in Berlin’s Olympic stadium next June.